Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all STK39 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 18 amino acid synthetic peptide from near the center of human Stk39. The immunogen is located within amino acids 360 - 410 of Stk39. Amino Acid Squence: KTEDGDWEWSDDEMDEKS

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Porcine (89%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for STK39 Antibody - BSA Free

Western Blot: STK39 AntibodyBSA Free [NBP1-76957]

Western Blot: STK39 AntibodyBSA Free [NBP1-76957]

Western Blot: STK39 Antibody [NBP1-76957] - Rat brain tissue lysate with STK39 antibody at (A) 1 and (B) 2 ug/mL.
STK39 Antibody - BSA Free

Immunohistochemistry: STK39 Antibody - BSA Free [NBP1-76957] -

Immunohistochemistry: STK39 Antibody - BSA Free [NBP1-76957] - Immunohistochemistry of STK39 in human brain tissue with STK39 antibody at 2.5 ugmL.

Applications for STK39 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: STK39

The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20 family is involved in diverse biological phenomena, including cell differentiation, cell transformation/ proliferation, cytoskeleton rearrangement, and the regulation of ion transporters. STK39 contains an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain and is abundantly expressed in the brain. STK39 is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled co-transporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Recent studies show that STK39 tend to be a novel candidate gene for autism and hypertension.

Alternate Names

DCHTsmall intestine SPAK-like kinase, DKFZp686K05124, EC 2.7.11, EC 2.7.11.1, PASK, proline-alanine-rich STE20-related kinase, serine threonine kinase 39, Serine/threonine-protein kinase 39, SPAKserine threonine kinase 39 (STE20/SPS1 homolog, yeast), STE20/SPS1 homolog, STE20/SPS1-related proline-alanine-rich protein kinase, Ste20-like protein kinase, Ste-20-related kinase

Gene Symbol

STK39

UniProt

NP_037365 (Human)

Additional STK39 Products

Product Documents for STK39 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for STK39 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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