Striatin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB110-74571

Novus Biologicals, part of Bio-Techne
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NB110-74571
NB110-74571SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human, Mouse, Rat

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Striatin Antibodies »

Product Specifications

Immunogen

Synthetic peptide made to an internal portion of the human Striatin protein (within residues 350-400). [Swiss-Prot# O43815]

Localization

Cell Membrane and Cytoplasmic

Specificity

This antibody specific for Striatin. It does not cross-react with SG2NA.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

110 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Striatin Antibody

Western Blot: Striatin Antibody [NB110-74571]

Western Blot: Striatin Antibody [NB110-74571]

Western Blot: Striatin Antibody [NB110-74571] - Immunoblot of PP2A immunoprecipitate with NB110-74571.
Immunocytochemistry/ Immunofluorescence: Striatin Antibody [NB110-74571]

Immunocytochemistry/ Immunofluorescence: Striatin Antibody [NB110-74571]

Immunocytochemistry/Immunofluorescence: Striatin Antibody [NB110-74571] - Immunofluorescent staining of NIH3T3 cells ± blocking peptide using NB110-74571.

Applications for Striatin Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:5000

Immunoprecipitation

1:10-1:500

Western Blot

1:500-1:5000
Application Notes
This Striatin antibody is useful in Western blot, Immunocytochemistry/Immunofluorescence and Immunoprecipitation. In WB a band can be seen at ~110 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole antisera

Preservative

0.02% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Striatin

Striatin (STRN) is a calmodulin-binding member of WD-repeat family of proteins/WD repeat striatin family and is an intracellular protein localized mainly in cytoplasm as well as in cellular membranes as peripheral membrane protein, and is mostly present in neurons of mammalian basal ganglia and cranial/spinal motor nuclei. Striatin's protein-protein interaction domains include caveolin-binding (amino acids 55-63), coiled-coil (amino acids 70-116), Ca2+-calmodulin-binding (amino acids 149-166), and a series of eight WD repeat (amino acids 419-780) motifs. Striatin is a scaffolding protein which functions in a calcium dependent fashion and is implicated in cellular signaling and trafficking processes. Striatin forms complex with PP2A (protein phosphatase 2A) which associates directly to and controls the function of ER-alpha. Moreover, striatin targets ER-alpha to the cell membrane and serves as a scaffold for the assembly of proteins essential to rapid, estrogen-induced eNOS activation. Striatin has also been suggested as a candidate gene for human ARVC (arrhythmogenic right ventricular cardiomyopathy), familial cardiac disease characterized by ventricular arrhythmias and sudden cardiac death.

Alternate Names

MGC125642, SG2NA, striatin, striatin, calmodulin binding protein, striatin, calmodulin-binding protein

Entrez Gene IDs

6801 (Human); 268980 (Mouse); 29149 (Rat)

Gene Symbol

STRN

UniProt

Q13033 (Human)

Additional Striatin Products

Product Documents for Striatin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Striatin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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