Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (100%), Chicken (100%). Backed by our 100% Guarantee.

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all SUR-8 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 21 amino acid synthetic peptide near the amino terminus of human SHOC2. The immunogen is located within amino acids 30 - 80 of SHOC2. Amino Acid Squence: KESKEKEPKTKGKDAKDGKK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SUR-8 Antibody - BSA Free

Western Blot: SUR-8 AntibodyBSA Free [NBP1-77041]

Western Blot: SUR-8 AntibodyBSA Free [NBP1-77041]

Western Blot: SUR-8 Antibody [NBP1-77041] - Jurkat cell lysate with at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry-Paraffin: SUR-8 Antibody - BSA Free [NBP1-77041]

Immunohistochemistry-Paraffin: SUR-8 Antibody - BSA Free [NBP1-77041]

Immunohistochemistry-Paraffin: SUR-8 Antibody [NBP1-77041] - Human spleen tissue at 5 ug/ml.
SUR-8 Antibody - BSA Free

Western Blot: SUR-8 Antibody - BSA Free [NBP1-77041] -

Western Blot: SUR-8 Antibody - BSA Free [NBP1-77041] - Western blot analysis of SUR-8 in Jurkat cell lysate with SUR-8 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide

Applications for SUR-8 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SUR-8

SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

Alternate Names

KIAA0862FLJ60412, Protein soc-2 homolog, Protein sur-8 homolog, SIAA0862, SOC-2, soc-2 (suppressor of clear, C.elegans) homolog, soc-2 suppressor of clear homolog (C. elegans), SOC2SUR8leucine-rich repeat protein SHOC-2, SUR-8

Gene Symbol

SHOC2

UniProt

NP_031399 (Human)

Additional SUR-8 Products

Product Documents for SUR-8 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for SUR-8 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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