SWAP70 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56430

Novus Biologicals, part of Bio-Techne
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NB100-56430
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (95%), Canine (95%), Mouse (90%), Primate (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all SWAP70 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 300-350 of human SWAP-70 was used as the immunogen.

Reactivity Notes

Predicted to react with Bovine, Chimpanzee, Canine and Mouse.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SWAP70 Antibody

Western Blot: SWAP70 Antibody [NB100-56430]

Western Blot: SWAP70 Antibody [NB100-56430]

Western Blot: SWAP70 Antibody [NB100-56430] - Analysis of SWAP-70 in Daudi cell lysate using this antibody.

Applications for SWAP70 Antibody

Application
Recommended Usage

Western Blot

1-3 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SWAP70

SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages.

Long Name

Switch-associated Protein 70 kDa

Alternate Names

KIAA0640SWAP-70FLJ39540, SWAP switching B-cell complex 70kDa subunit, switch-associated protein 70

Entrez Gene IDs

20947 (Mouse)

Gene Symbol

SWAP70

UniProt

Q9UH65

Additional SWAP70 Products

Product Documents for SWAP70 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SWAP70 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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