Synapsin I [p Ser62, p Ser67] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-745

Novus Biologicals, part of Bio-Techne
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NB300-745
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Mouse

Predicted:

Bovine (100%), Mouse (100%). Backed by our 100% Guarantee.

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Synapsin I Antibodies »

Product Specifications

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser62/67 conjugated to KLH. Accession # P17599

Modification

p Ser62, p Ser67

Localization

Cell junction; synapse

Specificity

Specific for endogenous levels of the ~78 kDa synapsin I doublet phosphorylated at Ser62,67. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.

Marker

pre-Synaptic Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

78 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Synapsin I [p Ser62, p Ser67] Antibody

Western Blot: Synapsin I [p Ser62, p Ser67] Antibody [NB300-745]

Western Blot: Synapsin I [p Ser62, p Ser67] Antibody [NB300-745]

Western Blot: Synapsin I [p Ser62, p Ser67] Antibody [NB300-745] - Western blot of rat cortex lyaste showing specific labeling of the ~78k Synapsin protein phosphorylated at Ser62,67 (Control). Immunolabeling is blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown).

Applications for Synapsin I [p Ser62, p Ser67] Antibody

Application
Recommended Usage

Western Blot

1:1000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Synapsin I

Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002). Ser 549 along with Ser 62 and Ser 67 are the sites of Synapsin I that are phosphorylated by MAP kinase (Czernik et al., 1987; Jovanovic et al., 1996).

Alternate Names

SYN1, phospho Synapsin

Entrez Gene IDs

20964 (Mouse); 24949 (Rat)

Gene Symbol

SYN1

Additional Synapsin I Products

Product Documents for Synapsin I [p Ser62, p Ser67] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Synapsin I [p Ser62, p Ser67] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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