SYNE1 Antibody (1D4D9)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15911

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15911-100ul
NBP3-15911-20ul
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 1D4D9

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SYNE1 Antibodies »

Product Specifications

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 8200-8400 of human SYNE1 (Q8NF91). FGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SYNE1 Antibody (1D4D9)

Immunocytochemistry/ Immunofluorescence: SYNE1 Antibody (1D4D9) [NBP3-15911]

Immunocytochemistry/ Immunofluorescence: SYNE1 Antibody (1D4D9) [NBP3-15911]

Immunocytochemistry/Immunofluorescence: SYNE1 Antibody (1D4D9) [NBP3-15911] - Immunofluorescence analysis of NIH-3T3 cells using SYNE1 Rabbit mAb (NBP3-15911) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Applications for SYNE1 Antibody (1D4D9)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50 - 1:200

Western Blot

1:500 - 1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SYNE1

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus.These proteins are called Nesprin l and 2 for nuclear envelope spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM domain-containing sequence essential for perinuclear localization. Nesprin l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as "dystrophins of the nucleus" to maintain nuclear organization and structural integrity. There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called Nesprin l and 2 for nuclear envelope spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as "dystrophins of the nucleus" to maintain nuclear organization and structural integrity.

Alternate Names

ARCA1, C6orf98, CPG2, dJ45H2.2, EC 4.2.1.49, EC 4.3.1.3, EDMD4, Enaptin, KIAA0796chromosome 6 open reading frame 98, KIAA1262FLJ41140, KIAA17568B, Myne-1, MYNE1DKFZp781J13156, Myocyte nuclear envelope protein 1, nesprin 1, nesprin-1, Nuclear envelope spectrin repeat protein 1, SCAR8FLJ30878, spectrin repeat containing, nuclear envelope 1, Synaptic nuclear envelope protein 1, synaptic nuclei expressed gene 1, Syne-1, SYNE-1B

Gene Symbol

SYNE1

Additional SYNE1 Products

Product Documents for SYNE1 Antibody (1D4D9)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SYNE1 Antibody (1D4D9)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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