SynGAP Antibody (8M2S9)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15787

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15787-100ul
NBP3-15787-20ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 8M2S9

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SynGAP Antibodies »

Product Summary for SynGAP Antibody (8M2S9)

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1244-1343 of human SynGAP (Q96PV0). SEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAPPAPPPPPRLQITENGEFRNTADH

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SynGAP Antibody (8M2S9)

Western Blot: SynGAP Antibody (8M2S9) [NBP3-15787]

Western Blot: SynGAP Antibody (8M2S9) [NBP3-15787]

Western Blot: SynGAP Antibody (8M2S9) [NBP3-15787] - Western blot analysis of extracts of various cell lines, using SynGAP Rabbit mAb (NBP3-15787) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Applications for SynGAP Antibody (8M2S9)

Application
Recommended Usage

Western Blot

1:500 - 1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SynGAP

Synaptic Ras GTPase Activating Protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.

Alternate Names

DKFZp761G1421, KIAA1938135kDa, MRD5, synaptic Ras GTPase activating protein 1, synaptic Ras GTPase activating protein 1 homolog (rat), Synaptic Ras-GAP 1

Gene Symbol

SYNGAP1

Additional SynGAP Products

Product Documents for SynGAP Antibody (8M2S9)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SynGAP Antibody (8M2S9)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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