SynGAP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27558

Novus Biologicals, part of Bio-Techne
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NBP2-27558
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Key Product Details

Species Reactivity

Validated:

Mouse

Predicted:

Bovine (100%), Canine (100%), Human (100%), Porcine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all SynGAP Antibodies »

Product Specifications

Immunogen

Peptide with sequence DEDEIHPLLIRDR-C corresponding to N-Terminus according to NP_006763.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for SynGAP Antibody

Western Blot: SynGAP Antibody [NBP2-27558]

Western Blot: SynGAP Antibody [NBP2-27558]

Western Blot: SynGAP Antibody [NBP2-27558] - NBP2-27558 (2ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for SynGAP Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 150 kDa band observed in mouse brain lysates (calculated MW of 148 kDa band according to human NP_006763.2 and mouse XP_990642.3).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SynGAP

Synaptic Ras GTPase Activating Protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.

Alternate Names

DKFZp761G1421, KIAA1938135kDa, MRD5, synaptic Ras GTPase activating protein 1, synaptic Ras GTPase activating protein 1 homolog (rat), Synaptic Ras-GAP 1

Entrez Gene IDs

240057 (Mouse); 192117 (Rat)

Gene Symbol

SYNGAP1

UniProt

NP_006763.2 (Human)

Additional SynGAP Products

Product Documents for SynGAP Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SynGAP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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