Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Rabbit (100%). Backed by our 100% Guarantee.

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all SYPL2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SYPL. The immunogen is located within the last 50 amino acids of SYPL2. Amino Acid Squence: DQGQGPSQESAAEQG

Specificity

At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SYPL2 Antibody - BSA Free

Western Blot: SYPL2 AntibodyBSA Free [NBP1-77362]

Western Blot: SYPL2 AntibodyBSA Free [NBP1-77362]

Western Blot: SYPL2 Antibody [NBP1-77362] - Human spleen tissue lysate with SYPL2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
SYPL2 Antibody - BSA Free

Immunohistochemistry: SYPL2 Antibody - BSA Free [NBP1-77362] -

Immunohistochemistry: SYPL2 Antibody - BSA Free [NBP1-77362] - Immunohistochemistry of SYPL2 in human spleen tissue with SYPL2 antibody at 2.5 ug/mL.
SYPL2 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: SYPL2 Antibody - BSA Free [NBP1-77362] -

Immunocytochemistry/ Immunofluorescence: SYPL2 Antibody - BSA Free [NBP1-77362] - Immunofluorescence of SYPL2 in Human Spleen cells with SYPL2 antibody at 20 ug/mL.

Applications for SYPL2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SYPL2

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores. At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.

Alternate Names

MG29, mitsugumin-29, synaptophysin-like 2, synaptophysin-like protein 2

Gene Symbol

SYPL2

UniProt

NP_001035799 (Human)

Additional SYPL2 Products

Product Documents for SYPL2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for SYPL2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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