Tankyrase binding protein 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89826

Novus Biologicals, part of Bio-Techne
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NBP1-89826
NBP1-89826-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Tankyrase binding protein 1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: DWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDLEVTCDPDSGGSQGLRGCGVGQMDWTQDLAPQNVELFGAPSEARE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Tankyrase binding protein 1 Antibody

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826] - Staining of human prostate.
Immunohistochemistry: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry: Tankyrase binding protein 1 Antibody [NBP1-89826] - Staining of human prostate shows strong cytoplasmic and membranous positivity in glandular cells.
Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826] - Staining of human skeletal muscle shows low expression as expected.
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Applications for Tankyrase binding protein 1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Tankyrase binding protein 1

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

Alternate Names

KIAA1741TAB182FLJ45975,182 kDa tankyrase-1-binding protein, tankyrase 1 binding protein 1, 182kDa, tankyrase 1-binding protein of 182 kDa

Gene Symbol

TNKS1BP1

Additional Tankyrase binding protein 1 Products

Product Documents for Tankyrase binding protein 1 Antibody

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Certificate of Analysis

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Product Specific Notices for Tankyrase binding protein 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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