Tankyrase binding protein 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-20561

Novus Biologicals, part of Bio-Techne
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NBP2-20561
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Tankyrase binding protein 1 Antibodies »

Product Specifications

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Tankyrase binding protein 1. The exact sequence is proprietary.

Localization

Nucleus; Cytoplasm

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

182 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Tankyrase binding protein 1 Antibody

Western Blot: Tankyrase binding protein 1 Antibody [NBP2-20561]

Western Blot: Tankyrase binding protein 1 Antibody [NBP2-20561]

Western Blot: Tankyrase binding protein 1 Antibody [NBP2-20561] - Sample (30 ug of whole cell lysate) A: A431 B: H1299 5% SDS PAGE gel, diluted at 1:1000.
Immunocytochemistry/ Immunofluorescence: Tankyrase binding protein 1 Antibody [NBP2-20561]

Immunocytochemistry/ Immunofluorescence: Tankyrase binding protein 1 Antibody [NBP2-20561]

Immunocytochemistry/Immunofluorescence: Tankyrase binding protein 1 Antibody [NBP2-20561] - Analysis of methanol-fixed A431, using antibody at 1:200 dilution.
Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP2-20561]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP2-20561]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP2-20561] - Immunohistochemical analysis of paraffin-embedded Brain cortex, using antibody at 1:100 dilution.

Applications for Tankyrase binding protein 1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:1000

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Tankyrase binding protein 1

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

Alternate Names

KIAA1741TAB182FLJ45975,182 kDa tankyrase-1-binding protein, tankyrase 1 binding protein 1, 182kDa, tankyrase 1-binding protein of 182 kDa

Gene Symbol

TNKS1BP1

UniProt

Q9C0C2 (Human)

Additional Tankyrase binding protein 1 Products

Product Documents for Tankyrase binding protein 1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Tankyrase binding protein 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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