TAO Kinase 1 Antibody (4E12)

Novus Biologicals, part of Bio-Techne | Catalog # H00057551-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG3 Kappa Clone # 4E12

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all TAO Kinase 1 Antibodies »

Product Specifications

Immunogen

TAOK1 (NP_065842, 892 a.a. ~ 1001 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. LSNLSPEAFSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT

Reactivity Notes

Human. Other species not tested.

Specificity

TAOK1 (4E12)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG3 Kappa

Scientific Data Images for TAO Kinase 1 Antibody (4E12)

Western Blot: TAO Kinase 1 Antibody (4E12) [H00057551-M01]

Western Blot: TAO Kinase 1 Antibody (4E12) [H00057551-M01]

Western Blot: TAO Kinase 1 Antibody (4E12) [H00057551-M01] - TAOK1 monoclonal antibody (M01), clone 4E12 Western Blot analysis of TAOK1 expression in HeLa ( Cat # L013V1 ).
Immunohistochemistry-Paraffin: TAO Kinase 1 Antibody (4E12) [H00057551-M01]

Immunohistochemistry-Paraffin: TAO Kinase 1 Antibody (4E12) [H00057551-M01]

Immunohistochemistry-Paraffin: TAO Kinase 1 Antibody (4E12) [H00057551-M01] - Analysis of monoclonal antibody to TAOK1 on formalin-fixed paraffin-embedded human testis. Antibody concentration 3 ug/ml.
Sandwich ELISA: TAO Kinase 1 Antibody (4E12) [H00057551-M01] - Detection limit for recombinant GST tagged TAOK1 is approximately 0.03ng/ml as a capture antibody.

Applications for TAO Kinase 1 Antibody (4E12)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against cell lysate and recombinant protein for Western Blot. Has also been used for immunohistochemistry (paraffin) and ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: TAO Kinase 1

TAOK1, a member of the Ste20 kinase family, is a TAO type protein kinase that acts as an upstream activator to MARK by phosphorylation. When activated, MARK enhances microtubule dynamics and leads to phosphorylation and detachment of tau or equivalent MAPs from microtubules. Overexpression of MARK eventually leads to microtubule breakdown and cell death, but in neuronal cells the primary effect is to allow the development of neurites during differentiation.

Long Name

Serine/threonine-protein kinase TAO1

Alternate Names

hKFC-B, hTAOK1, KIAA1361, MAP3K16, MARK Kinase, MARKK, PSK-2, PSK2, TAOK1

Entrez Gene IDs

57551 (Human)

Gene Symbol

TAOK1

UniProt

NP_065842 (Human)

Additional TAO Kinase 1 Products

Product Documents for TAO Kinase 1 Antibody (4E12)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TAO Kinase 1 Antibody (4E12)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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