TBK1 [p Ser172] Antibody (5B8P1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16918

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-16918-100ul
NBP3-16918-20ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 5B8P1

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TBK1 Antibodies »

Product Specifications

Immunogen

A synthetic phosphorylated peptide around S172 of human TBK1 (Q9UHD2). FVSLY

Modification

p Ser 172

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TBK1 [p Ser172] Antibody (5B8P1)

Western Blot: TBK1 [p Ser172] Antibody (5B8P1) [NBP3-16918] - Western blot analysis of extracts of various cell lines, using TBK1 Rabbit mAb (NBP3-16918) at 1:1000 dilution.Both HeLa cells and NIH/3T3 cells were treated by Calyculin A (100 nM) at 37C for 30 minutes after serum-starvation overnight. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit. Exposure time: 1min.

Applications for TBK1 [p Ser172] Antibody (5B8P1)

Application
Recommended Usage

Western Blot

1:500 - 1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TBK1

NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumour promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4).

Long Name

TANK Binding Kinase 1

Alternate Names

FTDALS4, NAK, NFKB-Activating Kinase

Gene Symbol

TBK1

Additional TBK1 Products

Product Documents for TBK1 [p Ser172] Antibody (5B8P1)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TBK1 [p Ser172] Antibody (5B8P1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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