TC-PTP/PTPN2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48528

Novus Biologicals, part of Bio-Techne
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NBP2-48528
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all TC-PTP Antibodies »

Product Summary for TC-PTP/PTPN2 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: DDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERK

Reactivity Notes

Mouse (81%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TC-PTP/PTPN2 Antibody

Western Blot: TC-PTP/PTPN2 Antibody [NBP2-48528]

Western Blot: TC-PTP/PTPN2 Antibody [NBP2-48528]

Western Blot: TC-PTP/PTPN2 Antibody [NBP2-48528] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11
Lane 2: Human cell line RT-4
Immunocytochemistry/ Immunofluorescence: TC-PTP/PTPN2 Antibody [NBP2-48528]

Immunocytochemistry/ Immunofluorescence: TC-PTP/PTPN2 Antibody [NBP2-48528]

Immunocytochemistry/Immunofluorescence: TC-PTP/PTPN2 Antibody [NBP2-48528] - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
Immunohistochemistry-Paraffin: TC-PTP/PTPN2 Antibody [NBP2-48528]

Immunohistochemistry-Paraffin: TC-PTP/PTPN2 Antibody [NBP2-48528]

Immunohistochemistry-Paraffin: TC-PTP/PTPN2 Antibody [NBP2-48528] - Staining of human kidney.
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Applications for TC-PTP/PTPN2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TC-PTP

PTPN2 is encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq]

Long Name

T Cell Protein Tyrosine Phosphatase

Alternate Names

PTP2, PTPN2, TCPTP

Gene Symbol

PTPN2

Additional TC-PTP Products

Product Documents for TC-PTP/PTPN2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TC-PTP/PTPN2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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