TC10 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-55239

Novus Biologicals, part of Bio-Techne
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NBP2-55239
NBP2-55239-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all TC10 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: FDEAIIAILTPKKHTVKKRIGSRCINCCLIT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TC10 Antibody

Immunocytochemistry/ Immunofluorescence: TC10 Antibody [NBP2-55239]

Immunocytochemistry/ Immunofluorescence: TC10 Antibody [NBP2-55239]

Immunocytochemistry/Immunofluorescence: TC10 Antibody [NBP2-55239] - Staining of human cell line SH-SY5Y shows localization to vesicles.

Applications for TC10 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
ICC/IF, Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TC10

TC10 is a member of the Rho family of GTP-binding proteins and is closely related to Cdc42 and Rac 1. Cycling between inactive and active GTP-bound state, active TC10 can directly interact with Cdc42 kinase, p21-activated protein kinases as well as other kinases (1). Constitutive expression of active TC10 mutants (TC10/Q75L) in fibroblast decrease actin stress fiber and formation of plasma membrane microspikes, while wild type TC10 has no effect on fibroblast cell morphology (2). Mostly expressed in adipose and muscle tissues, TC10 has been found to be activated by C3G (from the insulin pathway) in adipocytes (3).

Alternate Names

ARHQTC10A, ras homolog gene family, member Q, Ras-like protein family member 7A, Ras-like protein TC10, RAS-like, family 7, member A, rho-related GTP-binding protein RhoQ, TC10RASL7A

Gene Symbol

RHOQ

Additional TC10 Products

Product Documents for TC10 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TC10 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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