TCL1A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-77332

Novus Biologicals, part of Bio-Techne
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NB100-77332
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Key Product Details

Species Reactivity

Human

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all TCL1A Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-QLYPDGRYRSSD corresponding to internal region according to NP_068801.1.

Epitope

QLYPDGRYRSSD

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for TCL1A Antibody

Western Blot: TCL1A Antibody [NB100-77332]

Western Blot: TCL1A Antibody [NB100-77332]

Western Blot: TCL1 Antibody [NB100-77332] - (0.1ug/ml) staining of Jurkat Cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for TCL1A Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

0.1 - 0.3 ug/ml
Application Notes
WB: Approx. 16 kDa band observed in Daudi and Jurkat lysates (calculated MW of 13.5 kDa band according to NP_068801.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TCL1A

The T-cell leukaemia/lymphoma 1 (TCL1)-family oncoproteins augment AKT signal transduction and enhance cell proliferation and survival. Chromosome rearrangements, faulty developmental silencing and Epstein-Barr virus infection appear to dysregulate the expression of TCL1-family genes, provoking several important types of lymphocyte cancer. A key role for TCL1 proteins in cell transformation has been established in studies of transgenic mouse models, which develop a unique spectrum of T- and B-cell malignancies. How TCL1 proteins are regulated and dysregulated, how they promote transformation and the potential for therapies modelled on TCL1 interactions have important implications for understanding and treating lymphocyte cancers.

Long Name

T Cell Leukemia Protein 1A

Alternate Names

TCL1-PEN

Entrez Gene IDs

8115 (Human)

Gene Symbol

TCL1A

UniProt

NP_068801.1 (Human)

Additional TCL1A Products

Product Documents for TCL1A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TCL1A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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