TEM4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87862

Novus Biologicals, part of Bio-Techne
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NBP1-87862
NBP1-87862-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (96%), Rat (95%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all TEM4 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLW

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TEM4 Antibody

Immunocytochemistry/ Immunofluorescence: TEM4 Antibody [NBP1-87862]

Immunocytochemistry/ Immunofluorescence: TEM4 Antibody [NBP1-87862]

Immunocytochemistry/Immunofluorescence: TEM4 Antibody [NBP1-87862] - Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
Immunohistochemistry-Paraffin: TEM4 Antibody [NBP1-87862]

Immunohistochemistry-Paraffin: TEM4 Antibody [NBP1-87862]

Immunohistochemistry-Paraffin: TEM4 Antibody [NBP1-87862] - Staining of human heart muscle shows strong cytoplasmic positivity in myocytes.

Applications for TEM4 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TEM4

TEM4 (Tumor endothelial marker 4) is a Rho-specific GEF (guanine-nucleotide exchange factor) with novel structural and regulatory properties and predominant expression in the heart. Rho GTPases, which are activated by specific GEFs, play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful as a target, therapeutically.

Alternate Names

164 kDa Rho-specific guanine-nucleotide exchange factor, FLJ90019, KIAA0337P164RHOGEF, p164RhoGEF, p164-RhoGEFRho-specific guanine-nucleotide exchange factor 164 kDa, Rho guanine nucleotide exchange factor (GEF) 17, TEM4rho guanine nucleotide exchange factor 17, Tumor endothelial marker 4

Gene Symbol

ARHGEF17

Additional TEM4 Products

Product Documents for TEM4 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TEM4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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