Tenascin C Antibody (4C8MS) [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # NB110-68136H

Novus Biologicals, part of Bio-Techne
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NB110-68136H
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Feline

Cited:

Rat

Applications

Validated:

CyTOF-ready, ELISA, Flow (Intracellular), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Paraffin

Label

HRP

Antibody Source

Monoclonal Mouse IgG1 Clone # 4C8MS

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Tenascin C Antibodies »

Product Specifications

Immunogen

Recombinant human Tenascin C [Swiss-Prot# P24821].

Reactivity Notes

Feline reactivity reported in customer review.

Localization

Secreted > extracellular space > extracellular matrix

Specificity

NB110-68136 specifically reacts with Domain B on FNIII repeats of Tenascin C.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Tenascin C Antibody (4C8MS) [HRP]

Application
Recommended Usage

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow (Intracellular)

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Tenascin C

In most tissues of adults, tenascin C is rarely present at significant levels. However, in developing tissues, or tissues experiencing a fast rate of growth, tenascin C is upregulated. This effect is particularly evident when this extracellular matrix glycoprotein is found in abundance in tissues responding to injury or infection. When muscular pH is increased, tenascin C production also increases. Prostate smooth muscle cells produce extra tenascin C when responding to LPS infection. In fibrosis and stenosis, tenascin C expression levels are markedly increased, and the protein seems to function as a mobilizer of immune cells responding to tissue damage and repair. In COPD, likewise, tenascin C expression is increased and is associated with cells attempting to repair damage within the lung. In short, tenascin C can be expected to be found in adult tissues only when associated with tissue damage and repair efforts.

Alternate Names

Cytotactin, HXB, Tenascin J1, TNC

Gene Symbol

TNC

Additional Tenascin C Products

Product Documents for Tenascin C Antibody (4C8MS) [HRP]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Tenascin C Antibody (4C8MS) [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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