TFEB Antibody (CL14112)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26853

Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (94%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # CL14112

Concentration

1 mg/ml

View all TFEB Antibodies »

Product Summary for TFEB Antibody (CL14112)

Immunogen

This antibody was developed against a Synthetic Peptide of P19484. Actual immunogen sequence is proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for TFEB Antibody (CL14112)

TFEB Antibody (CL14112)

Immunohistochemistry-Paraffin: TFEB Antibody (CL14112) [NBP3-26853]

Staining of human small intestine shows strong nuclear positivity in glandular cells.
TFEB Antibody (CL14112)

Immunohistochemistry-Paraffin: TFEB Antibody (CL14112) [NBP3-26853]

Staining of human placenta shows strong nuclear positivity in trophoblastic cells.
TFEB Antibody (CL14112)

Immunohistochemistry-Paraffin: TFEB Antibody (CL14112) [NBP3-26853]

Staining of human cervix shows strong nuclear positivity in squamous epithelial cells.
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Applications for TFEB Antibody (CL14112)

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TFEB

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta

Long Name

Transcription Factor EB

Alternate Names

ALPHATFEB, BHLHE35, TCFEB

Gene Symbol

TFEB

Additional TFEB Products

Product Documents for TFEB Antibody (CL14112)

Product Datasheets

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Product Specific Notices for TFEB Antibody (CL14112)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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