THOC5 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-20621

Novus Biologicals, part of Bio-Techne
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NBP2-20621
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (95%), Mouse (94%), Primate (100%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all THOC5 Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human THOC5. The exact sequence is proprietary.

Reactivity Notes

Chimpanzee (100%), Chicken (84%).

Localization

Nucleus (By similarity); Cytoplasm (By similarity)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

79 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for THOC5 Antibody

Western Blot: THOC5 Antibody [NBP2-20621]

Western Blot: THOC5 Antibody [NBP2-20621]

Western Blot: THOC5 Antibody [NBP2-20621] - Sample (30 ug of whole cell lysate) A: 293T B: A431 C: HeLa 7. 5% SDS PAGE gel, diluted at 1:1000.
Immunohistochemistry-Paraffin: THOC5 Antibody [NBP2-20621]

Immunohistochemistry-Paraffin: THOC5 Antibody [NBP2-20621]

Immunohistochemistry-Paraffin: THOC5 Antibody [NBP2-20621] - Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using antibody at 1:500 dilution.

Applications for THOC5 Antibody

Application
Recommended Usage

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 20% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: THOC5

Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and THOC4. UAP56 functions as a bridge between THOC4 and the THO complex. THOC5 in conjunction with THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. May be involved in the differentiation of granulocytes and adipocytes.

Alternate Names

C22orf19, chromosome 22 open reading frame 19, FMIP, Fms-interacting protein, fSAP79hTREX90, Functional spliceosome-associated protein 79, KIAA0983, NF2/meningioma region protein pK1.3, PK1.3, Placental protein 39.2, PP39.2, THO complex 5, THO complex subunit 5 homolog

Gene Symbol

THOC5

UniProt

Q13769 (Human)

Additional THOC5 Products

Product Documents for THOC5 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for THOC5 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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