Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-42213JF646

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Janelia Fluor 646

Antibody Source

Monoclonal Mouse IgG1 Lambda Clone # 6C8.2F9

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Thrombomodulin/BDCA-3 Antibodies »

Product Summary for Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [Janelia Fluor® 646]

Immunogen

Partial recombinant human CD141 protein (between amino acids 200-400) [UniProt P07204].

Localization

Transmembrane protein with Extracellular, Helical and Cytoplasmic domains.

Marker

Endothelial Cells Damage Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 Lambda

Applications for Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [Janelia Fluor® 646]

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Thrombomodulin/BDCA-3

CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Alternate Names

BDCA-3, BDCA3, CD141, Fetomodulin, THBD, THRM

Gene Symbol

THBD

Additional Thrombomodulin/BDCA-3 Products

Product Documents for Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [Janelia Fluor® 646]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [Janelia Fluor® 646]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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