Thrombomodulin/BDCA-3 Antibody (QBEND/40)

Novus Biologicals, part of Bio-Techne | Catalog # NB100-64982

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Electron Microscopy, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # QBEND/40

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Thrombomodulin/BDCA-3 Antibodies »

Product Summary for Thrombomodulin/BDCA-3 Antibody (QBEND/40)

Immunogen

Human endothelium (thrombomodulin)

Reactivity Notes

Reacts with: Rabbit

Specificity

Recognizes all human endothelium tested. Preliminary evidence suggests that this recognizes Thrombomodulin, but does not inhibit Thrombomodulin dependent activation of protein C.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Thrombomodulin/BDCA-3 Antibody (QBEND/40)

Immunocytochemistry/ Immunofluorescence: Thrombomodulin/BDCA-3 Antibody (QBEND/40) [NB100-64982]

Immunocytochemistry/ Immunofluorescence: Thrombomodulin/BDCA-3 Antibody (QBEND/40) [NB100-64982]

Immunocytochemistry/Immunofluorescence: Thrombomodulin/BDCA-3 Antibody (QBEND/40) [NB100-64982] - Analysis of human tonsil cryosection.
Immunohistochemistry-Frozen: Thrombomodulin/BDCA-3 Antibody (QBEND/40) [NB100-64982]

Immunohistochemistry-Frozen: Thrombomodulin/BDCA-3 Antibody (QBEND/40) [NB100-64982]

Immunohistochemistry-Frozen: Thrombomodulin/BDCA-3 Antibody (QBEND/40) [NB100-64982] - Analysis of human spleen.
Immunohistochemistry-Paraffin: Thrombomodulin/BDCA-3 Antibody (QBEND/40) [NB100-64982]

Immunohistochemistry-Paraffin: Thrombomodulin/BDCA-3 Antibody (QBEND/40) [NB100-64982]

Immunohistochemistry-Paraffin: Thrombomodulin/BDCA-3 Antibody (QBEND/40) [NB100-64982] - Human lymph node.

Applications for Thrombomodulin/BDCA-3 Antibody (QBEND/40)

Application
Recommended Usage

Flow Cytometry

Neat

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:10-1:100

Immunohistochemistry-Paraffin

1:10-1:100
Application Notes
This product requires antigen retrieval using heat treatment methods prior to staining of paraffin sections. Sodium Citrate pH6.0 is recommended for this purpose.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Tissue culture supernatant

Formulation

0.2 M Tris-HCl (pH 7.4), 5 - 10% Fetal Bovine Serum (FBS)

Preservative

0.01% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Thrombomodulin/BDCA-3

CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Alternate Names

BDCA-3, BDCA3, CD141, Fetomodulin, THBD, THRM

Entrez Gene IDs

7056 (Human)

Gene Symbol

THBD

UniProt

P07204 (Mouse)

Additional Thrombomodulin/BDCA-3 Products

Product Documents for Thrombomodulin/BDCA-3 Antibody (QBEND/40)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Thrombomodulin/BDCA-3 Antibody (QBEND/40)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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