Thymidine Kinase 2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-92505

Novus Biologicals, part of Bio-Techne
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NBP1-92505
NBP1-92505-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Knockdown Validated, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Thymidine Kinase 2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: YVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRD

Reactivity Notes

Rat (81%), Mouse (81%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Thymidine Kinase 2 Antibody

Immunohistochemistry-Paraffin: Thymidine Kinase 2 Antibody [NBP1-92505]

Immunohistochemistry-Paraffin: Thymidine Kinase 2 Antibody [NBP1-92505]

Immunohistochemistry-Paraffin: Thymidine Kinase 2 Antibody [NBP1-92505] - Staining of human Testis shows strong granular cytoplasmic positivity in Leydig cells.
Immunohistochemistry-Paraffin: Thymidine Kinase 2 Antibody [NBP1-92505]

Immunohistochemistry-Paraffin: Thymidine Kinase 2 Antibody [NBP1-92505]

Immunohistochemistry-Paraffin: Thymidine Kinase 2 Antibody [NBP1-92505] - Staining of human kidney shows strong cytoplasmic positivity in renal tubules.
Immunohistochemistry-Paraffin: Thymidine Kinase 2 Antibody [NBP1-92505]

Immunohistochemistry-Paraffin: Thymidine Kinase 2 Antibody [NBP1-92505]

Immunohistochemistry-Paraffin: Thymidine Kinase 2 Antibody [NBP1-92505] - Staining of human heart muscle shows moderate granular cytoplasmic positivity in cardiomyocytes.
View 1 more images

Applications for Thymidine Kinase 2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Thymidine Kinase 2

The mitochondrial deoxyribonucleotide (dNTP) pool is separated from the cytosolic pool because the mitochondria inner membrane is impermeable to charged molecules. The mitochondrial pool is maintained by either import of cytosolic dNTPs through dedicated transporters or by salvaging deoxynucleosides within the mitochondria; apparently, enzymes of the de novo dNTP synthesis pathway are not present in the mitochondria. In nonreplicating cells, where cytosolic dNTP synthesis is downregulated, mtDNA synthesis depends solely on the mitochondrial salvage pathway enzymes, the deoxyribonucleoside kinases. Two of the 4 human deoxyribonucleoside kinases, deoxyguanosine kinase (DGK) and thymidine kinase-2, are expressed in mitochondria. Human DGK, encoded by the DGUOK gene (MIM 601465), efficiently phosphorylates deoxyguanosine and deoxyadenosine, whereas TK2 phosphorylates deoxythymidine, deoxycytidine, and deoxyuridine. Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs.[supplied by OMIM]

Alternate Names

EC 2.7.1.21, MTDPS2, MTTK, Mt-TK, thymidine kinase 2, mitochondrial

Gene Symbol

TK2

Additional Thymidine Kinase 2 Products

Product Documents for Thymidine Kinase 2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Thymidine Kinase 2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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