Thyroglobulin Antibody (TGB/1970R) [Janelia Fluor® 646]
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08265JF646
Recombinant Monoclonal Antibody
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Human, Mouse (Negative), Rat (Negative)
Applications
Immunohistochemistry-Paraffin
Label
Janelia Fluor 646
Antibody Source
Recombinant Monoclonal Rabbit IgG Clone # TGB/1970R
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Recombinant full-length human Thyroglobulin protein (Uniprot: P01266)
Reactivity Notes
Does not react with Mouse or Rat.
Localization
Cytoplasmic, Secreted
Specificity
Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Marker
Thyroidal Cell Marker
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Applications for Thyroglobulin Antibody (TGB/1970R) [Janelia Fluor® 646]
Application
Recommended Usage
Immunohistochemistry-Paraffin
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Thyroglobulin
Alternate Names
AITD3, cog, TDH3, Tg, TGN
Gene Symbol
TG
Additional Thyroglobulin Products
Product Documents for Thyroglobulin Antibody (TGB/1970R) [Janelia Fluor® 646]
Product Specific Notices for Thyroglobulin Antibody (TGB/1970R) [Janelia Fluor® 646]
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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