TIAL1 Antibody (6E3) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11834

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Primate

Applications

ELISA, Flow (Intracellular), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 6E3

Format

BSA Free

Concentration

1 mg/ml

View all TIAL1 Antibodies »

Product Summary for TIAL1 Antibody (6E3) - BSA Free

Immunogen

GST-tagged recombinant human TIAL1

Specificity

The mouse monoclonal antibody 6E3 recognizes TIAL1, an ubiquitously expressed approximately 42 kDa intracellular RNA-binding protein.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Scientific Data Images for TIAL1 Antibody (6E3) - BSA Free

Flow Cytometry: TIAL1 Antibody (6E3) - BSA Free [NBP3-11834]

Flow Cytometry: TIAL1 Antibody (6E3) - BSA Free [NBP3-11834]

Flow Cytometry: TIAL1 Antibody (6E3) [NBP3-11834] - Staining of TIAR in human cell line A-431 using purified mouse monoclonal antibody 6E3 (concentration in sample 5 ug/ml, GAM FITC, red-filled) from A-431 cells unstained by primary antibody (GAM FITC, black-dashed) in flow cytometry analysis (intracellular staining).

Applications for TIAL1 Antibody (6E3) - BSA Free

Application
Recommended Usage

Flow (Intracellular)

5 ug/ml

Flow Cytometry

5 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.9% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TIAL1

TIAL1 is an ubiquitously expressed RNA-binding protein, which regulates translational control, splicing, and other activities, including apoptosis. TIAL1 attenuates CDK1 activity, and is essential for the G2/M checkpoint. It accumulates in nuclear foci in late G2 phase and prophase in cells under replication stress. In steady state TIAL1 shuttles between the cytoplasm and the nucleus, probably as a part of nucleocytoplasmic transport of mRNA, but under stress conditions it accumulates mRNA molecules in granules and prevents their translation. Nucleolytic activity of TIAL1 against attacked target cells of cytotoxic lymphocytes has also been reported. Similarly, e.g. in permeabilized thymocytes TIAL1 triggers DNA fragmentation.

Alternate Names

aging-associated gene 7 protein, MGC33401, TCBP, T-cluster binding protein, TIA1 cytotoxic granule-associated RNA binding protein-like 1, TIA1 cytotoxic granule-associated RNA-binding protein-like 1, TIA-1 related protein, TIA-1-related nucleolysin, TIA-1-related protein, TIARnucleolysin TIAR

Gene Symbol

TIAL1

Additional TIAL1 Products

Product Documents for TIAL1 Antibody (6E3) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TIAL1 Antibody (6E3) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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