TLR10 Antibody (3C10C5)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11234

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Flow Cytometry, Immunoassay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 3C10C5

Concentration

0.1 mg/ml

View all TLR10 Antibodies »

Product Summary for TLR10 Antibody (3C10C5)

Immunogen

The extracellular domain of TLR10

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for TLR10 Antibody (3C10C5)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunoassay

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
For Immunoassays and Flow Cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 um filtered solution in PBS, 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: TLR10

The monoclonal antibody 3C10C5 reacts with human TLR-10, which is a type I transmembrane glycoprotein that consist of an extracellular domain, a single transmembrane segment and a cytoplasmic Toll/interleukin (IL)-1 receptor domain and has an apparent molecular mass of approximately 94kDa. In total humans possess 10 TLR family members (1-10). The TLR 10, 1, and 6 genes are tandemly arranged and seem to have arisen from duplication events. In accordance with their role in host defense, monocytes/macrophages express most TLRs, whereas the expression of individual TLRs in dendritic cells depends upon their subtype. The microbial agonists for TLRs include a wide variety of structures such as nucleic acids from bacteria and viruses, as well as outer membrane components of bacteria, fungi, and protozoan organisms. Despite extensive research on the TLRs, human TLR10 has remained an orphan receptor without a known agonist or function. Although recent studies have shown that the putative ligands include di- and triacetylated lipopeptides as can be found in bacteria. Variations in the TLR10 gene have been associated with several diseases such as papillary thyroid carcinoma, urothelial bladder cancer, and Crohn's disease. The monocalonal antibody 3C10C5 is suitable for immunoassay and flow cytometry.

Long Name

Toll-like Receptor 10

Alternate Names

CD290

Gene Symbol

TLR10

Additional TLR10 Products

Product Documents for TLR10 Antibody (3C10C5)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TLR10 Antibody (3C10C5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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