TMC6 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76892

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

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Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide from near the center of human EVER1. The immunogen is located within amino acids 560 - 610 of EVER1. Amino Acid Squence: SEKKLKRRRKPEFDI

Specificity

At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TMC6 Antibody - BSA Free

Western Blot: TMC6 AntibodyBSA Free [NBP1-76892]

Western Blot: TMC6 AntibodyBSA Free [NBP1-76892]

Western Blot: TMC6 Antibody [NBP1-76892] - Human spleen tissue lysate with TMC6 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry-Paraffin: TMC6 Antibody - BSA Free [NBP1-76892]

Immunohistochemistry-Paraffin: TMC6 Antibody - BSA Free [NBP1-76892]

Immunohistochemistry-Paraffin: TMC6 Antibody [NBP1-76892] - Human spleen with TMC6 antibody at 2.5 ug/ml.

Immunocytochemistry/Immunofluorescence: TMC6 Antibody [NBP1-76892] -

Immunocytochemistry/Immunofluorescence: TMC6 Antibody [NBP1-76892] - Human Spleen cells with EVER1 antibody at 20 ug/mL.
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Applications for TMC6 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TMC6

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance. At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.

Alternate Names

epidermodysplasia verruciformis 1, Epidermodysplasia verruciformis protein 1, EVER1FLJ17776, EVIN1EV1, expressed in activated T/LAK lymphocytes, LAK-4P, Protein LAK-4, transmembrane channel-like 6, transmembrane channel-like protein 6

Gene Symbol

TMC6

UniProt

AAM44452 (Human)

Additional TMC6 Products

Product Documents for TMC6 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TMC6 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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