Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (94%), Rabbit (94%). Backed by our 100% Guarantee.

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all TMEM38A Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38A. The immunogen is located within the last 50 amino acids of TMEM38A. Amino Acid Squence: KEELSEGSRKKKAKKAD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TMEM38A Antibody - BSA Free

Western Blot: TMEM38A AntibodyBSA Free [NBP1-76247]

Western Blot: TMEM38A AntibodyBSA Free [NBP1-76247]

Western Blot: TMEM38A Antibody [NBP1-76247] - Rat skeletal muscle tissue lysate with TMEM38A antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
TMEM38A Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: TMEM38A Antibody - BSA Free [NBP1-76247] -

Immunocytochemistry/ Immunofluorescence: TMEM38A Antibody - BSA Free [NBP1-76247] - Immunofluorescence of TMEM38A in mouse skeletal muscle tissue with TMEM38A antibody at 20 u/mL.

Applications for TMEM38A Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TMEM38A

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

Alternate Names

transmembrane protein 38ATRIC-AMGC3169, TRICA, trimeric intracellular cation channel type A

Gene Symbol

TMEM38A

UniProt

AAH01195 (Human)

Additional TMEM38A Products

Product Documents for TMEM38A Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TMEM38A Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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