TMEM38B Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-77093

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all TMEM38B Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38B. The immunogen is located within the last 50 amino acids of TMEM38B. Amino Acid Squence: VDVASDNVKKKHTKKNE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TMEM38B Antibody - BSA Free

Western Blot: TMEM38B AntibodyBSA Free [NBP1-77093]

Western Blot: TMEM38B AntibodyBSA Free [NBP1-77093]

Western Blot: TMEM38B Antibody [NBP1-77093] - Rat thymus tissue lysate with TMEM38B antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry-Paraffin: TMEM38B Antibody - BSA Free [NBP1-77093]

Immunohistochemistry-Paraffin: TMEM38B Antibody - BSA Free [NBP1-77093]

Immunohistochemistry-Paraffin: TMEM38B Antibody [NBP1-77093] - Mouse thymus tissue with TMEM38B antibody at 5 ug/mL.

Immunohistochemistry: TMEM38B Antibody [NBP1-77093] -

Immunohistochemistry: TMEM38B Antibody [NBP1-77093] - Mouse thymus tissue with TMEM38B antibody at 20 ug/mL.

Applications for TMEM38B Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TMEM38B

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

Alternate Names

bA219P18.1, chromosome 9 open reading frame 87, D4Ertd89e, FLJ10493, transmembrane protein 38BC9orf87, TRIC-BTRICB, trimeric intracellular cation channel type B

Gene Symbol

TMEM38B

UniProt

NP_060582 (Human)

Additional TMEM38B Products

Product Documents for TMEM38B Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TMEM38B Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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