Tmp21/p23 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48969

Novus Biologicals, part of Bio-Techne
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NBP2-48969
NBP2-48969-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Validated:

Human

Predicted:

Mouse (94%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Tmp21/p23 Antibodies »

Product Summary for Tmp21/p23 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: SFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDATKGKFAFTTEDYD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Tmp21/p23 Antibody

Western Blot: Tmp21/p23 Antibody [NBP2-48969]

Western Blot: Tmp21/p23 Antibody [NBP2-48969]

Western Blot: Tmp21/p23 Antibody [NBP2-48969] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10
Lane 2: Human cell line RT-4
Lane 3: Human cell line U-251MG sp
Immunohistochemistry-Paraffin: Tmp21/p23 Antibody [NBP2-48969]

Immunohistochemistry-Paraffin: Tmp21/p23 Antibody [NBP2-48969]

Immunohistochemistry-Paraffin: Tmp21/p23 Antibody [NBP2-48969] - Staining of human kidney.
Immunohistochemistry-Paraffin: Tmp21/p23 Antibody [NBP2-48969]

Immunohistochemistry-Paraffin: Tmp21/p23 Antibody [NBP2-48969]

Immunohistochemistry-Paraffin: Tmp21/p23 Antibody [NBP2-48969] - Staining of human stomach shows cytoplasmic positivity in glandular cells.
View 7 more images

Applications for Tmp21/p23 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Tmp21/p23

TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase, but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites, and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21, indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity and Abeta production, but not epsilon-secretase activity, demonstrating that TMP21 can modulate gamma-secretase activity.

Long Name

21 kDa Transmembrane Trafficking Protein

Alternate Names

p24delta, S31I125, S31III125, TMED10

Gene Symbol

TMED10

Additional Tmp21/p23 Products

Product Documents for Tmp21/p23 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Tmp21/p23 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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