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TOB1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-55845

Novus Biologicals, part of Bio-Techne
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NBP2-55845
NBP2-55845-25ul

Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (91%), Rat (91%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: STKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQPQQQ

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TOB1 Antibody

Immunocytochemistry/ Immunofluorescence: TOB1 Antibody [NBP2-55845]

Immunocytochemistry/ Immunofluorescence: TOB1 Antibody [NBP2-55845]

Immunocytochemistry/Immunofluorescence: TOB1 Antibody [NBP2-55845] - Staining of human cell line MCF7 shows localization to nucleoplasm & vesicles.
Immunohistochemistry-Paraffin: TOB1 Antibody [NBP2-55845]

Immunohistochemistry-Paraffin: TOB1 Antibody [NBP2-55845]

Immunohistochemistry-Paraffin: TOB1 Antibody [NBP2-55845] - Immunohistochemical staining of human adrenal gland shows nuclear positivity in glandular cells.

Applications for TOB1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TOB1

TOB1 encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells. [provided by RefSeq]

Long Name

Transducer of ERBB2 Protein 1

Alternate Names

PIG49, TROB1

Gene Symbol

TOB1

Additional TOB1 Products

Product Documents for TOB1 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for TOB1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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