TOP2A Antibody (RM394)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18827

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-18827
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM394

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TOP2A Antibodies »

Product Specifications

Immunogen

A peptide corresponding to Human TOP2A (Uniprot # P11388)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TOP2A Antibody (RM394)

TOP2A Antibody (RM394)

Immunohistochemistry: TOP2A Antibody (RM394)[NBP3-18827]

Immunohistochemistry: TOP2A Antibody (RM394)[NBP3-18827]Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using anti-TOP2A rabbit monoclonal antibody (Clone RM394) at a 1:100 dilution.

Applications for TOP2A Antibody (RM394)

Application
Recommended Usage

Immunohistochemistry

1:100-1:2000

Western Blot

1:1000-1:2000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C.

Background: TOP2A

Topo II Alpha encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Long Name

DNA Topoisomerase II alpha

Alternate Names

TOP2, TP2A

Gene Symbol

TOP2A

Additional TOP2A Products

Product Documents for TOP2A Antibody (RM394)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TOP2A Antibody (RM394)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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