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TPMT Antibody (SR1518)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22563

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
Catalog #
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NBP3-22563-100ul
NBP3-22563-50ul

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Flow Cytometry, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1518

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Summary for TPMT Antibody (SR1518)

Immunogen

A synthesized peptide derived from human TPMT (Uniprot #: P51580)

Specificity

Detects endogenous levels of total TPMT

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

30 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TPMT Antibody (SR1518)

Western Blot: TPMT Antibody (SR1518) [NBP3-22563] -

Western Blot: TPMT Antibody (SR1518) [NBP3-22563] - Western blot analysis using NBP3-22563 in Jurkat cell lysate.

Applications for TPMT Antibody (SR1518)

Application
Recommended Usage

Flow Cytometry

1:50

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TPMT

TPMT encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Long Name

Thiopurine S-methyltransferase

Alternate Names

EC 2.1.1.67

Gene Symbol

TPMT

Additional TPMT Products

Product Documents for TPMT Antibody (SR1518)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for TPMT Antibody (SR1518)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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