TPX2 Antibody (18D5-1)

Novus Biologicals, part of Bio-Techne | Catalog # NB100-74556

Novus Biologicals, part of Bio-Techne
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NB100-74556-0.025mg
NB100-74556
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 18D5-1

Concentration

1 mg/ml

View all TPX2 Antibodies »

Product Specifications

Immunogen

Recombinant human TPX2

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Localization

Nuclear. During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus.

Specificity

TPX2 (18D5-1)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for TPX2 Antibody (18D5-1)

Western Blot: TPX2 Antibody (18D5-1) [NB100-74556]

Western Blot: TPX2 Antibody (18D5-1) [NB100-74556]

Western Blot: TPX2 Antibody (18D5-1) [NB100-74556] - Analysis of TPX2.
Immunohistochemistry-Paraffin: TPX2 Antibody (18D5-1) [NB100-74556]

Immunohistochemistry-Paraffin: TPX2 Antibody (18D5-1) [NB100-74556]

Immunohistochemistry-Paraffin: TPX2 Antibody (18D5-1) [NB100-74556] - Biopsies of deparaffinized Human testis tissue.

Applications for TPX2 Antibody (18D5-1)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

4 ug/mL

Immunohistochemistry

1:200

Immunohistochemistry-Paraffin

0.5 - 1.0 ug/ml

Immunoprecipitation

1:10 - 1:500

Western Blot

2 ug/mL

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TPX2

TPX2 is essential for spindle pole and mitotic spindle formulation, playing a role in the S and G2 phases of mitosis. It is also critical for the function of protein kinase Aurora A. TPX2 autophosphorylates Aurora A, targeting it to the spindle apparatus and allowing it to function in eukaryotic meiotic and mitotic cell cycles. TPX2 has also been found to be highly expressed in cancer cells.

Alternate Names

C20orf1HCTP4, C20orf2, chromosome 20 open reading frame 1, Differentially expressed in cancerous and non-cancerous lung cells 2, differentially expressed in lung cells, DIL2, DIL-2FLS353, HCA519, Hepatocellular carcinoma-associated antigen 519, P100, p100GD:C20orf1, preferentially expressed in colorectal cancer, Protein fls353, REPP86, restricted expression proliferation associated protein 100, Restricted expression proliferation-associated protein 100, targeting protein for Xklp2, TPX2, microtubule-associated protein homolog, TPX2, microtubule-associated, homolog (Xenopus laevis)

Entrez Gene IDs

22974 (Human); 72119 (Mouse); 311546 (Rat)

Gene Symbol

TPX2

Additional TPX2 Products

Product Documents for TPX2 Antibody (18D5-1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TPX2 Antibody (18D5-1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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