TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386)

Novus Biologicals, part of Bio-Techne | Catalog # NB100-61088

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 2386

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TR beta 1/NR1A2 Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH. Accession # P10828

Specificity

Specific for endogenous levels of the ~55 kDa TR beta 1/NR1A2/Thyroid Hormone Receptor beta protein.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386)

Western Blot: TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386) [NB100-61088]

Western Blot: TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386) [NB100-61088]

Western Blot: TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386) [NB100-61088] - Analysis of Thyroid Hormone, b-isotype in brain lysate using this antibody at 1:1000. Showing specific immunolabeling of the 58k TR-a protein.

Applications for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386)

Application
Recommended Usage

Western Blot

1:1000

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TR beta 1/NR1A2

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Long Name

Thyroid Hormone Receptor beta 1

Alternate Names

NR1A2, THRB, v-ErbA2

Entrez Gene IDs

7068 (Human)

Gene Symbol

THRB

UniProt

P10828 (Human)

Additional TR beta 1/NR1A2 Products

Product Documents for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TR beta 1/NR1A2/Thyroid Hormone Receptor beta Antibody (2386)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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