TREX1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-29617

Novus Biologicals, part of Bio-Techne
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NBP2-29617
NBP2-29617SS
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all TREX1 Antibodies »

Product Summary for TREX1 Antibody - BSA Free

Immunogen

Partial recombinant protein made to an internal portion of human TREX1 protein (between residues 200-350) [NP_057465.1]

Localization

Nucleus, Cytoplasm

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TREX1 Antibody - BSA Free

Western Blot: TREX1 AntibodyBSA Free [NBP2-29617]

Western Blot: TREX1 AntibodyBSA Free [NBP2-29617]

Western Blot: TREX1 Antibody [NBP2-29617] - Analysis of TREX1 partial recombinant protein by using TREX1 antibody at a concentration of 1ug/ml.
Immunohistochemistry-Frozen: TREX1 Antibody - BSA Free [NBP2-29617]

Immunohistochemistry-Frozen: TREX1 Antibody - BSA Free [NBP2-29617]

Immunohistochemistry-Frozen: TREX1 Antibody [NBP2-29617] - Analysis of FFPE tissue section of human normal stomach using rabbit polyclonal TREX1 antibody at 7.5 ug/ml concentration. Specific cytoplasmic and nuclear staining was observed in the glandular cells/mucosal epithelium of stomach [Magnification 10X].
Immunohistochemistry-Paraffin: TREX1 Antibody - BSA Free [NBP2-29617]

Immunohistochemistry-Paraffin: TREX1 Antibody - BSA Free [NBP2-29617]

Immunohistochemistry-Paraffin: TREX1 Antibody [NBP2-29617] - Analysis of TREX1 protein in a transverse section of normal skeletal muscle from human using 7.5 ug/ml concentration of TREX1 antibody. Specific staining was observed in the cytoplasm and the nuclei of the myocytes.
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Applications for TREX1 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

5-10 ug/ml

Immunohistochemistry-Frozen

5-10 ug/ml

Immunohistochemistry-Paraffin

5-10 ug/ml

Western Blot

1-2 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TREX1

Trex1 is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. TREX1 antibody will not cross-react with the related protein TREX2.

Alternate Names

3'-5' exonuclease TREX1, AGS1, Aicardi-Goutieres syndrome 1, CRV, DKFZp434J0310, DNase III, DRN3, EC 3.1.11.2, HERNS, three prime repair exonuclease 1,3' repair exonuclease 1

Entrez Gene IDs

11277 (Human)

Gene Symbol

TREX1

UniProt

Q9NSU2 (Human)

Additional TREX1 Products

Product Documents for TREX1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TREX1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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