TRIB3 Antibody (1H2)

Western Blot: TRIB3 Antibody (1H2) [H00057761-M03]

Western Blot: TRIB3 Antibody (1H2) [H00057761-M03] - TRIB3 over-expressed 293 cell line, cotransfected with TRIB3 Validated Chimera RNAi or non-transfected control. Blot probed with H00057761-M03. GAPDH (36.1 kDa) used as loading control.

Knockout Validated: TRIB3 Antibody (1H2) [H00057761-M03]

Knockout Validated: TRIB3 Antibody (1H2) [H00057761-M03] - Representative images and colony numbers of LCs from the indicated groups with or withoutTRIB3(H00057761-M03) deletion Data are presented as the means+/- S.E.M from three independent experiments. Statistical significance was determined by two-tailed Studentst test.P value: 0.0005, 0.0032. 0.0097, and 0.0074. Scale bar, 50um. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/33298911/) licensed under a CC-BY license.

Western Blot: TRIB3 Antibody (1H2) [H00057761-M03] -

Western Blot: TRIB3 Antibody (1H2) [H00057761-M03] - Disturbing the TRIB3/MYC interaction attenuates lymphoma in mice.a The strategy for investigating the anti-BCL effects of PCM4 on MycEμ mice in vivo. b, c The data represent the statistical analyses of spleen & LN weights in MycEμ mice (5 months old; n = 7 per group) treated with the indicated agents. Data are represented as means ± SEM. Statistical significance was determined by two-tailed Student’s t test. P value: 0.016; 0.0108, & 0.0038 (b); 0.003, 0.0003, 7.34 × 10−5 (c). d Representative images of Ki67 staining (left) & statistical analyses of Ki67-positive cells (right) in the spleens of MycEμ mice (5 months old; n = 12 per group) treated with the indicated agents. Scale bar, 50 μm. Data are represented as means ± SEM. Statistical significance was determined by two-tailed Student’s t test. P value: 1.28 × 10−9, 7.86 × 10−10, & 1.13 × 10−9. e The tumorigenicity of BCL cells from the indicated mice was compared by limiting dilution transplantation into NSG mice; n = 8 mice per group. f PCM4 disturbed the TRIB3/MYC interaction in vivo. Spleen lysates from the indicated mice (5 months old) were IP with an anti-TRIB3 Ab & blotted with an anti-MYC Ab. The data are representative of three independent assays. g PCM4-reduced MYC expression. LN & spleen extracts from the indicated mice (5 months old) were blotted with an anti-MYC Ab. The data are presented as representative from three independent experiments. h Kaplan–Meier survival curves for MycEμ BCL mice treated with the indicated agents (n = 10 per group). Statistical difference was determined by two-sided log-rank test. P value: 0.0214 (DOX + PCM4 vs. DOX + PCON). Source data are provided as a Source Data file. Image collected & cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33298911), licensed under a CC-BY license. Not internally tested by Novus Biologicals.