Trk (pan) Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-12168

Novus Biologicals, part of Bio-Techne
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NBP3-12168
NBP3-12168-0.1ml
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Trk (pan) Antibodies »

Product Specifications

Immunogen

Peptide-KLH conjugate with human Trk A (777-796aa)

Localization

Cytoplasm

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for Trk (pan) Antibody

Immunohistochemistry-Paraffin: Trk (pan) Antibody [NBP3-12168]

Immunohistochemistry-Paraffin: Trk (pan) Antibody [NBP3-12168]

Immunohistochemistry-Paraffin: Trk (pan) Antibody [NBP3-12168] - Formalin fixed paraffin embedded human Cerebellum stained with Trk (pan) antibody (NBP3-12168)

Applications for Trk (pan) Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
IHC-P: recommended pretreatement of EDTA buffer, pH 8.0. Recommended incubation time of 30 min at RT.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 0.2% BSA, Tween-20

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4°C.

Background: Trk (pan)

Neurotrophic tyrosine kinase receptor (NTRK) is a family of 3 proto-oncogenes including NTRK1, NTRK2, and NTRK3 which encode Trk A, Trk B, and Trk C proteins, respectively. The latter are involved in biological processes such as neuronal survival, differentiation, and plasticity under physiological circumstances. In various cancers, oncogenic fusions involving the kinase domain of NTRK1, 2, or 3 are present. Pan-Trk IHC is a time- and tissue-efficient screen for NTRK fusions, particularly in drivernegative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma. Pan-Trk IHC can help determine whether translation occurs for novel NTRK rearrangements.

Alternate Names

High affinity nerve growth factor receptor;MTC;NTRK1;Nucleoprotein TPR;p140-TrkA;Protein TFG;TRK;TRK1;TRKA;Trk-A;Tyrosine-protein kinase receptor

Gene Symbol

NTRK1

Additional Trk (pan) Products

Product Documents for Trk (pan) Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Trk (pan) Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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