TROY/TNFRSF19 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB120-12126

Novus Biologicals, part of Bio-Techne
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NB120-12126
NB120-12126SS
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all TROY/TNFRSF19 Antibodies »

Product Specifications

Immunogen

This rabbit polyclonal antibody was developed by immunizing rabbits with a mixture of synthetic peptides corresponding to amino acids 29-44, 204-219, and 409-421 of human TROY (Genbank Accession No. AB040434).

Localization

Type I membrane protein (Probable).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TROY/TNFRSF19 Antibody

Western Blot: TROY/TNFRSF19 Antibody [NB120-12126]

Western Blot: TROY/TNFRSF19 Antibody [NB120-12126]

Western Blot: TROY Antibody [NB120-12126] - Analysis of TROY using NB120-12126 in T98G, a human glioblastoma cell line lysate. A protein band of approximately 46 kD is detected.

Applications for TROY/TNFRSF19 Antibody

Application
Recommended Usage

Western Blot

0.5-2 ug/ml
Application Notes
WB: Detects a band of approximately 46 kDa (predicted molecular weight: 50.8 kDa). For optimal results, primary antibody incubations should be performed at room temperature.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TROY/TNFRSF19

Analysis of EST clones and use of a signal sequence trap screening of the murine brain have lead to identification of a new member of the tumor necrosis factor receptor superfamily designated as TAJ and TROY, respectively. TAJ/TROY is a membrane protein of 423 amino acids with characteristic cysteine-rich motifs in the extracellular domain and a tumor necrosis factor receptor-associated factor (TRAF) 2 binding sequence in the cytoplasmic domain. Human TROY has 78% identity at the amino acid level with mouse TROY. The extracellular domain of TROY has significant homology with that of EDAR (another newly identified receptor belonging to TNF receptor family) that specifies hair follicle fate. The cytoplasmic domain of TAJ is different than other TNF receptor family members. Although its cytoplasmic domain does not contain death domain, TAJ/TROY induced cell death is probably mediated through a caspase-independent pathway. TAJ-induced JNK activation was not blocked by dominant-negative inhibitors of TRAF2, TRAF5, or ASK1, which have been previously implicated in JNK activation via TNFR1 and CD40. However, coimmunoprecipitation assays revealed that TAJ is capable of binding a number of different TRAF family members, and it is possible that TAJ-induced JNKactivation is mediated by an as yet untested TRAF homolog, such as TRAF6. TROY mRNA is highly expressed in brain, prostate and embryo and moderately expressed in the heart, lung, liver.

Long Name

Tumor Necrosis Factor Receptor Superfamily, Member 19

Alternate Names

TAJ, TNFRSF19

Entrez Gene IDs

55504 (Human); 29820 (Mouse)

Gene Symbol

TNFRSF19

UniProt

Q9NS68

Additional TROY/TNFRSF19 Products

Product Documents for TROY/TNFRSF19 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TROY/TNFRSF19 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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