TRPM7 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB500-243

Novus Biologicals, part of Bio-Techne
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NB500-243
NB500-243SS
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Key Product Details

Species Reactivity

Human, Mouse (Negative)

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all TRPM7 Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to the C-terminal region of rat TRPM7. [UniProt# Q925B3]

Reactivity Notes

It does not work on endogenous samples tested for western analysis (human, rat and mouse cell lines).

Localization

Cell Membrane

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for TRPM7 Antibody

Application
Recommended Usage

Immunoprecipitation

5 ul

Western Blot

1:1000
Application Notes
This TRPM7 antibody is useful for Western blot on immunoprecipitated samples only, does not work on endogenous samples tested to date. The investigator should determine the optimal working dilution.

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole antisera

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TRPM7

Melastatin-like transient receptor potential (TRPM) subfamilies are a diverse group of voltage-independent Ca2+-permeable cation channels expressed in mammalian cells and among them, TRPM6 /TRPM7 are unique as they possess an enzyme domain in their C termini and are regulated by intracellular levels of Mg2+-complexed nucleotides. TRPM7 is a multi-pass membrane essential ion channel and serine/threonine-protein kinase which is a divalent cation channel permeable to Ca2+/Mg2+ ions. TRPM7 plays a key role in Mg2+ ion homeostasis and in the regulation of anoxic neuronal cell death. It also participates in maintaining the plasma membrane divalent cation fluxes according to cell's metabolic state. TRPM7 interacts with PLCB1 for generating TRPM6/7 heterodimers and TRPM6/7 are widely expressed ion channels associated with cell proliferation and survival. TRPM6/7 mutations have been linked to a hereditary form of hypomagnesaemia caused by impaired Mg2+ reabsorption. Moreover, defective TRPM7 causes increased susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 (ALS-PDC1).

Alternate Names

CHAK, CHAK1FLJ25718, Channel-kinase 1, EC 2.7.11.1, Long transient receptor potential channel 7, LTRPC ion channel family member 7, LTrpC7, LTrpC-7, LTRPC7FLJ20117, transient receptor potential cation channel subfamily M member 7, transient receptor potential cation channel, subfamily M, member 7, transient receptor potential-phospholipase C-interacting kinase, TRP-PLIK

Entrez Gene IDs

54822 (Human); 58800 (Mouse)

Gene Symbol

TRPM7

Additional TRPM7 Products

Product Documents for TRPM7 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TRPM7 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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