Tryptase alpha/beta 1 Antibody (rTPSAB1/1963) [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-24177H

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-24177H
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin

Label

HRP

Antibody Source

Recombinant Monoclonal Mouse IgG1 kappa Clone # rTPSAB1/1963

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Tryptase alpha/beta 1 Antibodies »

Product Summary for Tryptase alpha/beta 1 Antibody (rTPSAB1/1963) [HRP]

Immunogen

Recombinant human Tryptase alpha/beta 1 protein fragment (around aa 100-250) (exact sequence is proprietary)

Localization

Secreted. Cytoplasm.

Specificity

This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type.

Marker

Mast Cell Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Applications for Tryptase alpha/beta 1 Antibody (rTPSAB1/1963) [HRP]

Application
Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Tryptase alpha/beta 1

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

Alternate Names

alpha-Tryptase, EC:3.4.21.59, epididymis secretory sperm binding protein, mast cell alpha II tryptase, mast cell beta I tryptase, mast cell tryptase, TPS1, TPS2, TPSAB1, TPSB1, TPSB2, Tryptase 1, tryptase alpha II, Tryptase alpha-1, tryptase beta I, tryptase beta-1, Tryptase beta-2, Tryptase I, tryptase II, tryptase-1, tryptase-2, tryptase-I, tryptase-III

Gene Symbol

TPSAB1

Additional Tryptase alpha/beta 1 Products

Product Documents for Tryptase alpha/beta 1 Antibody (rTPSAB1/1963) [HRP]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Tryptase alpha/beta 1 Antibody (rTPSAB1/1963) [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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