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TTBK1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76989

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

Product Specifications

Immunogen

Antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human TTBK1. The immunogen is located within amino acids 1190 - 1240 of TTBK1. Amino Acid Squence: DLRPKQPPGRGLGPGR

Specificity

Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

140 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TTBK1 Antibody - BSA Free

Western Blot: TTBK1 AntibodyBSA Free [NBP1-76989]

Western Blot: TTBK1 AntibodyBSA Free [NBP1-76989]

Western Blot: TTBK1 Antibody [NBP1-76989] - Western blot analysis of TTBK1 in Jurkat lysate with TTBK1 antibody at 1 ug/ml.
Immunocytochemistry/ Immunofluorescence: TTBK1 Antibody - BSA Free [NBP1-76989]

Immunocytochemistry/ Immunofluorescence: TTBK1 Antibody - BSA Free [NBP1-76989]

Immunocytochemistry/Immunofluorescence: TTBK1 Antibody [NBP1-76989] - Immunofluorescence of TTBK1 in Human Brain cells with TTBK1 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: TTBK1 Antibody - BSA Free [NBP1-76989]

Immunohistochemistry-Paraffin: TTBK1 Antibody - BSA Free [NBP1-76989]

Immunohistochemistry-Paraffin: TTBK1 Antibody [NBP1-76989] - Mouse brain tissue with TTBK1 antibody at 2.5 ug/mL.

Applications for TTBK1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TTBK1

Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.

Alternate Names

BDTK, Brain-derived tau kinase, EC 2.7.11, EC 2.7.11.1, KIAA1855tau-tubulin kinase 1, RP3-330M21.4, tau tubulin kinase 1

Gene Symbol

TTBK1

UniProt

Additional TTBK1 Products

Product Documents for TTBK1 Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for TTBK1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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