Tubby Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-1922

Novus Biologicals, part of Bio-Techne
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NB100-1922
NB100-1922SS
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Key Product Details

Species Reactivity

C. elegans

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Tubby Antibodies »

Product Specifications

Immunogen

Recombinant C. elegans Tubby (domain residues 160-421). [UniProt# Q09306]

Localization

Cytoplasmic

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Tubby Antibody

Western Blot: Tubby Antibody [NB100-1922]

Western Blot: Tubby Antibody [NB100-1922]

Western Blot: Tubby Antibody [NB100-1922] - Detection of tub-1 (GFP complex) using NB 100-1922. Tub-1 (nr2004) was used as a negative control.

Applications for Tubby Antibody

Application
Recommended Usage

Immunohistochemistry

1:50-1:200

Immunohistochemistry-Paraffin

1:50-1:200

Immunoprecipitation

1:10-1:500

Western Blot

1:1000
Application Notes
This Tubby antibody is useful inUseful in Immunohistochemistry-Paraffin, Immunoprecipitation and Western Blot.

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole antisera

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Tubby

Tubby (TUB) and tubby-like protein-1 (Tulp-1) belongs to tubby protein family that include members such as Tubby, Tulp-1, -2 and -3; Tulps etc. which share a highly conserved C-terminal region of 'tubby domain' with about 260 amino acids.Tubby is the founding member of its family and is expressed in ciliated sensory neurons with cytoplasmic localization. Tubby is associated with PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) on the inner leaflet of plasma membrane through its C-terminal domain and receptor-mediated activation of Galphaq (G protein alphaq) releases tubby from the plasma membrane followed by triggering its nuclear translocation. Tubby interacts with rgb-3 and plays a key a role in DAF-16 independent fat regulation as well as in ciliar sensory function which is required for normal sensory behavior such as chemotaxis. Tubby functions in life span control via insulin/IGF-1 pathway and is proposed to be involved in neuronal trafficking also. The naturally occurring tubby mutation in mouse causes retinitis pigmentosa, cochlear degeneration/hearing loss and adult-onset obesity.

Long Name

Tubby Bipartite Transcription Factor

Alternate Names

RD5, RDOB, Tubby Homolog

Entrez Gene IDs

174312 (C. elegans)

Gene Symbol

TUB

UniProt

Q09306 (C. elegans)

Additional Tubby Products

Product Documents for Tubby Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Tubby Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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