TWEAK/TNFSF12 Antibody (CARL-1) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-09144

Novus Biologicals, part of Bio-Techne
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NBP3-09144
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Flow Cytometry, Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG3 Kappa Clone # CARL-1

Format

BSA Free

Concentration

1 mg/ml

View all TWEAK/TNFSF12 Antibodies »

Product Summary for TWEAK/TNFSF12 Antibody (CARL-1) - BSA Free

Immunogen

human TWEAK/TNFSF12-transfected 2PK-3 cells

Specificity

The mouse monoclonal antibody CARL-1 recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG3 Kappa

Scientific Data Images for TWEAK/TNFSF12 Antibody (CARL-1) - BSA Free

Flow Cytometry: TWEAK/TNFSF12 Antibody (CARL-1) - BSA Free [NBP3-09144]

Flow Cytometry: TWEAK/TNFSF12 Antibody (CARL-1) - BSA Free [NBP3-09144]

Flow Cytometry: TWEAK/TNFSF12 Antibody (CARL-1) [NBP3-09144] - Separation of CD255 transfected L5178Y cells (red-filled) from nontransfected L5178Y cells (black-dashed) in flow cytometry analysis (surface staining) stained using anti-human CD255 (CARL-1) purified antibody (concentration in sample 9 ug/ml) GAM APC.

Applications for TWEAK/TNFSF12 Antibody (CARL-1) - BSA Free

Application
Recommended Usage

Flow Cytometry

1-4 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

TBS, pH 8.0

Format

BSA Free

Preservative

0.9% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TWEAK/TNFSF12

CD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia. ITEM-4 antibody reacts with both mouse and human Fn14. It is useful for flow cytometric analysis.

Long Name

TNF-like and Weak Inducer of Apoptosis

Alternate Names

TNFSF12

Gene Symbol

TNFSF12

Additional TWEAK/TNFSF12 Products

Product Documents for TWEAK/TNFSF12 Antibody (CARL-1) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TWEAK/TNFSF12 Antibody (CARL-1) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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