TXNIP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27095

Novus Biologicals, part of Bio-Techne
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NBP2-27095
NBP2-27095SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Monkey, Primate

Cited:

Human, Mouse, Rat, Monkery

Predicted:

Orangutan (98%), Porcine (96%). Backed by our 100% Guarantee.

Applications

Validated:

Western Blot

Cited:

IF/IHC, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all TXNIP Antibodies »

Product Specifications

Immunogen

A portion of amino acids 100-150 of human TxNIP was used as the immunogen.

Reactivity Notes

Rat reactivity reported in scientific literature (Singatulina et al). Use in Mouse reported in scientific literature (PMID:32164364).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TXNIP Antibody

Western Blot: TXNIP Antibody [NBP2-27095]

Western Blot: TXNIP Antibody [NBP2-27095]

Western Blot: TXNIP Antibody [NBP2-27095] - Analysis of TXNIP in Raji cell lysate in the 1) absence and 2) presence of immunizing peptide using this antibody. Goat anti-rabbit IgG HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for TXNIP Antibody

Application
Recommended Usage

Western Blot

2-4ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TXNIP

Thioredoxin-interacting protein belongs to the arrestin family. It acts as an oxidative stress mediator by inhibiting thioredoxin activity or by inhibiting thioredoxin activity or by limiting its bioavailability. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells. Recently reported, TXNIP deficiency led to the impairment of NLRP3 inflammasome activation to innate immune responses and reduced secretion of interleukin IL-1Beta .

Alternate Names

HHCPA78, THIF, thioredoxin binding protein 2, thioredoxin interacting protein, Thioredoxin-binding protein 2, thioredoxin-interacting protein, upregulated by 1,25-dihydroxyvitamin D-3, VDUP1EST01027, Vitamin D3 up-regulated protein 1

Gene Symbol

TXNIP

UniProt

Q9H3M7 (Human)

Additional TXNIP Products

Product Documents for TXNIP Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TXNIP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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