UAF1/WDR48 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-86034

Novus Biologicals, part of Bio-Techne
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NBP2-86034-0.1ml
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.5 mg/ml

View all UAF1 Antibodies »

Product Summary for UAF1/WDR48 Antibody

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of human UAF1/WDR48. Peptide sequence: LKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKEE The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for UAF1/WDR48 Antibody

Western Blot: UAF1/WDR48 Antibody [NBP2-86034]

Western Blot: UAF1/WDR48 Antibody [NBP2-86034]

Western Blot: UAF1/WDR48 Antibody [NBP2-86034] - Host: Rabbit. Target Name: WDR48. Sample Tissue: Human Hela Whole Cell. Antibody Dilution: 1.0ug/ml

Applications for UAF1/WDR48 Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: UAF1

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediateddeubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity ofcomplexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnoverwithout increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirussaimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein(TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptorTCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection bypapillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1

Long Name

USP1-associated Factor 1

Alternate Names

P80, WDR48

Gene Symbol

WDR48

Additional UAF1 Products

Product Documents for UAF1/WDR48 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for UAF1/WDR48 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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