UAF1/WDR48 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-95220

Novus Biologicals, part of Bio-Techne
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NBP2-95220-0.02ml
NBP2-95220-0.1ml
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all UAF1 Antibodies »

Product Summary for UAF1/WDR48 Antibody - BSA Free

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 450-677 of human WDR48 (NP_065890.1). FSSPDGSDPKLNLGGLLLQALLEYWPRTHVNPMDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYRQKST

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for UAF1/WDR48 Antibody - BSA Free

Western Blot: UAF1/WDR48 AntibodyBSA Free [NBP2-95220]

Western Blot: UAF1/WDR48 AntibodyBSA Free [NBP2-95220]

Western Blot: UAF1/WDR48 Antibody [NBP2-95220] - Analysis of extracts of various cell lines, using UAF1/WDR48 at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 15s.
Immunohistochemistry-Paraffin: UAF1/WDR48 Antibody - BSA Free [NBP2-95220]

Immunohistochemistry-Paraffin: UAF1/WDR48 Antibody - BSA Free [NBP2-95220]

Immunohistochemistry-Paraffin: UAF1/WDR48 Antibody [NBP2-95220] - Paraffin-embedded rat liver using UAF1/WDR48 .
Immunohistochemistry-Paraffin: UAF1/WDR48 Antibody - BSA Free [NBP2-95220]

Immunohistochemistry-Paraffin: UAF1/WDR48 Antibody - BSA Free [NBP2-95220]

Immunohistochemistry-Paraffin: UAF1/WDR48 Antibody [NBP2-95220] - Paraffin-embedded human liver using UAF1/WDR48 .
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Applications for UAF1/WDR48 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:50-1:100

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.3), 50% glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: UAF1

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediateddeubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity ofcomplexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnoverwithout increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirussaimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein(TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptorTCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection bypapillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1

Long Name

USP1-associated Factor 1

Alternate Names

P80, WDR48

Gene Symbol

WDR48

Additional UAF1 Products

Product Documents for UAF1/WDR48 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for UAF1/WDR48 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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