UBASH3B/STS1/Tula-2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-34053

Novus Biologicals, part of Bio-Techne
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NBP2-34053
NBP2-34053-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (99%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all UBASH3B/STS1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: CEDSKVDALGEALQTTVSRWKCKFSAPLPLELYTSSNFIGLFVKEDSAEVLKKFAADFAAEAASKTEVHVEPHKKQLHVTLAYHFQASH

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for UBASH3B/STS1/Tula-2 Antibody

Immunocytochemistry/ Immunofluorescence: UBASH3B/STS1/Tula-2 Antibody [NBP2-34053]

Immunocytochemistry/ Immunofluorescence: UBASH3B/STS1/Tula-2 Antibody [NBP2-34053]

Immunocytochemistry/Immunofluorescence: UBASH3B/STS1/Tula-2 Antibody [NBP2-34053] - Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
Immunohistochemistry-Paraffin: UBASH3B/STS1/Tula-2 Antibody [NBP2-34053]

Immunohistochemistry-Paraffin: UBASH3B/STS1/Tula-2 Antibody [NBP2-34053]

Immunohistochemistry-Paraffin: UBASH3B/STS1/Tula-2 Antibody [NBP2-34053] - Staining of human lymph node shows strong cytoplasmic positivity in germinal and non germinal center cells.

Applications for UBASH3B/STS1/Tula-2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: UBASH3B/STS1

Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation. Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2. Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.

Long Name

Ubiquitin Associated and SH3 Domain Containing Protein B

Alternate Names

Cbl-interacting Protein p70, STS1

Gene Symbol

UBASH3B

UniProt

Q8TF42 (Human)

Additional UBASH3B/STS1 Products

Product Documents for UBASH3B/STS1/Tula-2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for UBASH3B/STS1/Tula-2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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