Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all UBQLN4/CIP75 Antibodies »

Product Specifications

Immunogen

Antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CIP75. The immunogen is located within the first 50 amino acids of CIP75. Amino Acid Squence: SVKEFKEEISRRFKAQQD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for UBQLN4/CIP75 Antibody - BSA Free

Western Blot: UBQLN4/CIP75 AntibodyBSA Free [NBP1-77054]

Western Blot: UBQLN4/CIP75 AntibodyBSA Free [NBP1-77054]

Western Blot: UBQLN4/CIP75 Antibody [NBP1-77054] - 3T3 cell lysate with UBQLN4/CIP75 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry-Paraffin: UBQLN4/CIP75 Antibody - BSA Free [NBP1-77054]

Immunohistochemistry-Paraffin: UBQLN4/CIP75 Antibody - BSA Free [NBP1-77054]

Immunohistochemistry-Paraffin: UBQLN4/CIP75 Antibody [NBP1-77054] - Mouse kidney tissue with UBQLN/CIP75 antibody at 5 ug/ml.
UBQLN4/CIP75 Antibody - BSA Free

Immunohistochemistry: UBQLN4/CIP75 Antibody - BSA Free [NBP1-77054] -

Immunohistochemistry: UBQLN4/CIP75 Antibody - BSA Free [NBP1-77054] - Immunohistochemistry of UBQLN4/CIP75 in mouse kidney tissue with UBQLN4/CIP75 antibody at 5 u/mL.
View 1 more images

Applications for UBQLN4/CIP75 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: UBQLN4/CIP75

The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.

Alternate Names

A1Uataxin-1 ubiquitin-like interacting protein, Ataxin-1 ubiquitin-like-interacting protein A1U, C1orf6ubiquilin-4, chromosome 1 open reading frame 6, UBINCIP75, ubiquilin 4

Gene Symbol

UBQLN4

UniProt

Q9NRR5 (Human)

Additional UBQLN4/CIP75 Products

Product Documents for UBQLN4/CIP75 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for UBQLN4/CIP75 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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