UBR2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-88759

Novus Biologicals, part of Bio-Techne
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NBP1-88759
NBP1-88759-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (91%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all UBR2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: MASELEPEVQAIDRSLLECSAEEIAGKWLQATDLTREVYQHLAHYVPKIYCRGPNPFPQKEDMLAQHVLLGPMEWYLCGEDPAFGFPKLEQANKPSHLCGRV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for UBR2 Antibody

Immunocytochemistry/ Immunofluorescence: UBR2 Antibody [NBP1-88759]

Immunocytochemistry/ Immunofluorescence: UBR2 Antibody [NBP1-88759]

Immunocytochemistry/Immunofluorescence: UBR2 Antibody [NBP1-88759] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.
Immunohistochemistry-Paraffin: UBR2 Antibody [NBP1-88759]

Immunohistochemistry-Paraffin: UBR2 Antibody [NBP1-88759]

Immunohistochemistry-Paraffin: UBR2 Antibody [NBP1-88759] - Staining of human thyroid gland shows cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: UBR2 Antibody [NBP1-88759]

Immunohistochemistry-Paraffin: UBR2 Antibody [NBP1-88759]

Immunohistochemistry-Paraffin: UBR2 Antibody [NBP1-88759] - Staining of human smooth muscle shows strong cytoplasmic positivity.

Applications for UBR2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: UBR2

Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM]

Alternate Names

bA49A4.1, C6orf133MGC71112, chromosome 6 open reading frame 133, dJ242G1.1, dJ392M17.3, DKFZp686C08114, E3 ubiquitin-protein ligase UBR2, EC 6.3.2.-, KIAA0349FLJ36357, N-recognin-2, RP3-392M17.3, ubiquitin protein ligase E3 component n-recognin 2, Ubiquitin-protein ligase E3-alpha-2, Ubiquitin-protein ligase E3-alpha-II

Gene Symbol

UBR2

Additional UBR2 Products

Product Documents for UBR2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for UBR2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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